The Simpsons has been played on NTS shows including Whodis? w/ 56 DJs, with Deep, Deep Trouble (Dance Mix Edit) first played on 17 August 2017.

The Simpsons is an American animated television sitcom created by Matt Groening that has aired on the Fox Broadcasting Company since December 1989. It is a satirical parody of a middle class American lifestyle epitomized by its eponymous family, which consists of Homer, Marge, Bart, Lisa and Maggie. The show is set in the fictional town of Springfield, and lampoons American culture, society, and many aspects of the human condition. The popularity of The Simpsons led to the release of the 1990 double platinum album The Simpsons Sing the Blues, which contains original songs performed by the cast members of the show as their characters. The album spawned two hit singles—"Do the Bartman" and "Deep, Deep Trouble". A less successful sequel, The Yellow Album, was released in 1998.

Three soundtrack albums featuring music and songs from the show have been released—Songs in the Key of Springfield in 1997, Go Simpsonic with The Simpsons in 1999, and The Simpsons: Testify in 2007. The first two charted on the US Billboard 200, reaching number 103 and 197, respectively. The Simpsons Movie: The Music, a soundtrack album featuring the score of The Simpsons Movie, was released along with the feature-length film in July 2007. The choral piece "Spider Pig" that appeared in the film and on the soundtrack entered the charts in several countries around the world.